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Tip: To quickly search the same gene in another data set, click the links from the last column. The locuslink number will be used as query.
|No||ID||Symbol||Gene Name||Alias Symbols||Accession||Official Symbol||LocusLink||Probe Type||Ave. HEK CREB p-value||Ave. HEK CREB Binding Ratio||Hepatocyte_CREB p-value||Hepatocyte_CREB Binding Ratio||Hepatocyte_P-CREB p-value||Hepatocyte_P-CREB Binding Ratio||Islet_P-CREB p-value||Islet_P-CREB Binding Ratio||HEK_0h_CREB p-value||HEK_0h_CREB Binding Ratio||HEK_1h_CREB p-value||HEK_1h_CREB Binding Ratio||HEK_4h_CREB p-value||HEK_4h_CREB Binding Ratio||HEK_0h_P-CREB p-value||HEK_0h_P-CREB Binding Ratio||HEK_1h_P-CREB p-value||HEK_1h_P-CREB Binding Ratio||HEK_4h_P-CREB p-value||HEK_4h_P-CREB Binding Ratio||CRE prediction||CREflag||Chr. Location||Note||Link|
|1||Hp1_70_6_12||TOP1||topoisomerase (DNA) I||TOPI||NM_003286||TOP1||7150||promoter||2.2E-10||4.5||3.4E-07||2.8||1.3E-07||4.2||2.0E-03||1.3||3.0E-09||4.5||6.9E-11||4.5||1.1E-07||4.6||8.5E-09||2.9||4.4E-12||4.5||5.5E-10||4.2||CRE_TATA||3HT||chr20_39459267_39460267||"all, CREBtarget"||HEK293T_Expression Human_CRE_prediction Pancreatic_Islet_Expression|
Genome-wide location analysis (ChIP-chip) of CREB binding
Two values are reported for every ChIP-chip experiment. P-value is the confidence
level of the binding, and binding ratio is the ratio of ChIP signal over control
The recommended cutoff to choose ChIP positive genes is: p-value <= 0.001 and binding ratio>=2.
Please note the sensitivity of ChIP-on-chip using this cutoff is about 50%. If you see a gene with binding ratio somewhere between 1.5 and 2, there is a good chance that it may be a CREB target, especially if there is a good CRE on the promoter. Manual ChIP might be needed to verify CREB binding for these genes.
Both CREB and P-CREB ChIP is performed in each tissue type except pancreatic
islet, where only P-CREB yields useful data. In HEK293T cells, three time points,
0hr, 1hr and 4hr after forskolin stimulation are shown, as well as the average
of the three time points for CREB ChIPs.
For RefSeq genes whose promoters have been analyzed, the prediction of CRE sites is shown. The last column shows locations of probes that have been mapped to the May 2004 assembly of the human genome.
ID: unique ID number on the array
Accession numbers: Genbank accession numbers or Ensemble gene ID.
Probe type: genomic region where the probe is targeting: promoter, non-coding RNA, and controls (intergenic region or coding region).