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No probe set Gene Name Accession LocusLink Symbol Alias Symbols Description CTRL FSK (FSK vs CTRL) FC (FSK vs CTRL) LFC Note Link
1 203597_s_at WW domain binding protein 4 (formin binding protein 21) AI73422811193WBP4 FBP21 gb:AI734228 /DB_XREF=gi:5055341 /DB_XREF=zb57d10.y5 /CLONE=IMAGE:307699 /FEA=FLmRNA /CNT=102 /TID=Hs.28307.0 /TIER=Stack /STK=11 /UG=Hs.28307 /LL=11193 /UG_GENE=WBP4 /UG_TITLE=WW domain binding protein 4 (formin binding protein 21) /FL=gb:NM_007187.2 gb:AF071185.1 171.37 154.45 -1.11 -0.8 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
2 203599_s_at WW domain binding protein 4 (formin binding protein 21) NM_00718711193WBP4 FBP21 "gb:NM_007187.2 /DB_XREF=gi:9943844 /GEN=WBP4 /FEA=FLmRNA /CNT=102 /TID=Hs.28307.0 /TIER=FL+Stack /STK=25 /UG=Hs.28307 /LL=11193 /DEF=Homo sapiens WW domain binding protein 4 (formin binding protein 21) (WBP4), mRNA. /PROD=WW domain-containing binding protein 4 /FL=gb:NM_007187.2 gb:AF071185.1" 232.19 221.38 -1.05 -0.86 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
3 203598_s_at WW domain binding protein 4 (formin binding protein 21) AK00097911193WBP4 FBP21 "gb:AK000979.1 /DB_XREF=gi:7021977 /FEA=FLmRNA /CNT=102 /TID=Hs.28307.0 /TIER=Stack /STK=11 /UG=Hs.28307 /LL=11193 /UG_GENE=WBP4 /UG_TITLE=WW domain binding protein 4 (formin binding protein 21) /DEF=Homo sapiens cDNA FLJ10117 fis, clone HEMBA1002810, highly similar to Homo sapiens formin binding protein 21 mRNA. /FL=gb:NM_007187.2 gb:AF071185.1" 218.07 210.04 -1.04 -0.92 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction

Sample Description:
Primary culture of human pancreatic islet was treated with cAMP agonist forskolin (FSK) and compared with control untreated samples. RNA was extracted using the Qiagen RNeasy kit. Two control and two forskolin treated samples were analyzed.

Microarray Analysis:
Total RNA samples were labeled and hybridized by standard protocol to Affymetrix GeneChip Human Genome U133A 2.0 Array. Array data was analyzed using the dChip software with PM-MM models.

Guidelines for Choosing camp Induced Genes in this Data Set:
The fold change (FC) value is positive for increased expression and negative for decrease expression. There is also a lower bound of fold change (LFC), which is a conservative estimation of the fold change with 90% confidence. For this data set, if a gene was induced by FSK with LFC>=1.3, we consider it as a good camp induced gene and therefore a potential CREB target.