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No probe set Gene Name Accession LocusLink Symbol Alias Symbols Description CTRL FSK (FSK vs CTRL) FC (FSK vs CTRL) LFC Note Link
1 211491_at "adrenergic, alpha-1A-, receptor" D32202148ADRA1A ADRA1C;ADRA1L1 "gb:D32202.1 /DB_XREF=gi:927208 /FEA=FLmRNA /CNT=1 /TID=Hs.52931.2 /TIER=FL /STK=0 /UG=Hs.52931 /LL=148 /UG_GENE=ADRA1A /DEF=Human mRNA for alpha 1C adrenergic receptor isoform 2, complete cds. /PROD=alpha 1C adrenergic receptor isoform 2 /FL=gb:D32202.1" 156.16 162.31 1.04 0.8 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
2 211490_at "adrenergic, alpha-1A-, receptor" AF013261148ADRA1A ADRA1C;ADRA1L1 "gb:AF013261.1 /DB_XREF=gi:2978555 /FEA=FLmRNA /CNT=1 /TID=Hs.52931.1 /TIER=FL /STK=0 /UG=Hs.52931 /LL=148 /UG_GENE=ADRA1A /DEF=Homo sapiens alpha 1A adrenergic receptor isoform 4 mRNA, complete cds. /PROD=alpha 1A adrenergic receptor isoform 4 /FL=gb:AF013261.1" 190.3 181.34 -1.05 -0.78 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
3 211492_s_at "adrenergic, alpha-1A-, receptor" U02569148ADRA1A ADRA1C;ADRA1L1 "gb:U02569.1 /DEF=Human alpha1C adrenergic receptor mRNA, complete cds. /FEA=mRNA /PROD=alpha1C adrenergic receptor /DB_XREF=gi:409028 /UG=Hs.52931 adrenergic, alpha-1A-, receptor /FL=gb:U02569.1 gb:D25235.1 gb:NM_000680.1 gb:L31774.1" 752.18 728.18 -1.03 -0.78 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
4 211489_at "adrenergic, alpha-1A-, receptor" D32201148ADRA1A ADRA1C;ADRA1L1 "gb:D32201.1 /DB_XREF=gi:927210 /FEA=FLmRNA /CNT=1 /TID=Hs.52931.0 /TIER=FL /STK=0 /UG=Hs.52931 /LL=148 /UG_GENE=ADRA1A /DEF=Human mRNA for alpha 1C adrenergic receptor isoform 3, complete cds. /PROD=alpha 1C adrenergic receptor isoform 3 /FL=gb:D32201.1" 675.92 556.06 -1.22 -0.95 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction

Sample Description:
Primary culture of human pancreatic islet was treated with cAMP agonist forskolin (FSK) and compared with control untreated samples. RNA was extracted using the Qiagen RNeasy kit. Two control and two forskolin treated samples were analyzed.

Microarray Analysis:
Total RNA samples were labeled and hybridized by standard protocol to Affymetrix GeneChip Human Genome U133A 2.0 Array. Array data was analyzed using the dChip software with PM-MM models.

Guidelines for Choosing camp Induced Genes in this Data Set:
The fold change (FC) value is positive for increased expression and negative for decrease expression. There is also a lower bound of fold change (LFC), which is a conservative estimation of the fold change with 90% confidence. For this data set, if a gene was induced by FSK with LFC>=1.3, we consider it as a good camp induced gene and therefore a potential CREB target.