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No probe set Gene Name Accession LocusLink Symbol Alias Symbols Description CTRL FSK (FSK vs CTRL) FC (FSK vs CTRL) LFC Note Link
1 222142_at cylindromatosis (turban tumor syndrome) AK0242121540CYLD CDMT;CYLD1;EAC;HSPC057;KIAA0849 "Consensus includes gb:AK024212.1 /DEF=Homo sapiens cDNA FLJ14150 fis, clone MAMMA1003026, highly similar to Homo sapiens HSPC057 mRNA. /FEA=mRNA /DB_XREF=gi:10436534 /UG=Hs.18827 KIAA0849 protein" 89.52 107.91 1.21 0.87 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
2 221903_s_at cylindromatosis (turban tumor syndrome) BF5164331540CYLD CDMT;CYLD1;EAC;HSPC057;KIAA0849 Consensus includes gb:BE046443 /FEA=EST /DB_XREF=gi:8363496 /DB_XREF=est:hn47d10.x2 /CLONE=IMAGE:3026803 /UG=Hs.18827 KIAA0849 protein 306.11 317.89 1.04 0.81 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
3 60084_at cylindromatosis (turban tumor syndrome) AI4530991540CYLD CDMT;CYLD1;EAC;HSPC057;KIAA0849 "Cluster Incl. AI453099:tj61e11.x1 Homo sapiens cDNA, 3 end /clone=IMAGE-2146028 /clone_end=3' /gb=AI453099 /gi=4307988 /ug=Hs.24668 /len=554" 70.43 73.99 1.05 0.79 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
4 214272_at cylindromatosis (turban tumor syndrome) AI3620181540CYLD CDMT;CYLD1;EAC;HSPC057;KIAA0849 gb:AI362018 /DB_XREF=gi:4113639 /DB_XREF=qy39a11.x1 /CLONE=IMAGE:2014364 /FEA=EST /CNT=15 /TID=Hs.18827.1 /TIER=Stack /STK=9 /UG=Hs.18827 /LL=23296 /UG_GENE=KIAA0849 /UG_TITLE=KIAA0849 protein 626.24 548.1 -1.14 -0.83 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
5 221905_at cylindromatosis (turban tumor syndrome) BF5164331540CYLD CDMT;CYLD1;EAC;HSPC057;KIAA0849 Consensus includes gb:BF516433 /FEA=EST /DB_XREF=gi:11601612 /DB_XREF=est:UI-H-BW1-aoc-a-03-0-UI.s1 /CLONE=IMAGE:3084173 /UG=Hs.18827 KIAA0849 protein 139.22 123 -1.13 -0.94 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction

Sample Description:
Primary culture of human pancreatic islet was treated with cAMP agonist forskolin (FSK) and compared with control untreated samples. RNA was extracted using the Qiagen RNeasy kit. Two control and two forskolin treated samples were analyzed.

Microarray Analysis:
Total RNA samples were labeled and hybridized by standard protocol to Affymetrix GeneChip Human Genome U133A 2.0 Array. Array data was analyzed using the dChip software with PM-MM models.

Guidelines for Choosing camp Induced Genes in this Data Set:
The fold change (FC) value is positive for increased expression and negative for decrease expression. There is also a lower bound of fold change (LFC), which is a conservative estimation of the fold change with 90% confidence. For this data set, if a gene was induced by FSK with LFC>=1.3, we consider it as a good camp induced gene and therefore a potential CREB target.