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No probe set Gene Name Accession LocusLink Symbol Alias Symbols Description CTRL FSK (FSK vs CTRL) FC (FSK vs CTRL) LFC Note Link
1 216047_x_at seizure related 6 homolog (mouse)-like AL05025323544SEZ6L KIAA0927 "Consensus includes gb:AL050253.1 /DEF=H.sapiens mRNA similar to D29763 mouse mRNA for seizure-related gene product 6. Shares domains with BMPs, Tolloid, Sushi repeat proteins. /FEA=mRNA /PROD=hypothetical protein /DB_XREF=gi:4886438 /UG=Hs.194766 seizure related gene 6 (mouse)-like" 406.09 393.57 -1.03 -0.8 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
2 207873_x_at seizure related 6 homolog (mouse)-like NM_02111523544SEZ6L KIAA0927 "gb:NM_021115.1 /DEF=Homo sapiens seizure related gene 6 (mouse)-like (SEZ6L), mRNA. /FEA=mRNA /GEN=SEZ6L /PROD=seizure related gene 6 (mouse)-like /DB_XREF=gi:10863914 /UG=Hs.194766 seizure related gene 6 (mouse)-like /FL=gb:NM_021115.1" 425.9 390.47 -1.09 -0.93 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
3 213609_s_at seizure related 6 homolog (mouse)-like AB02314423544SEZ6L KIAA0927 "gb:AB023144.1 /DB_XREF=gi:4589485 /GEN=KIAA0927 /FEA=mRNA /CNT=47 /TID=Hs.194766.1 /TIER=Stack /STK=12 /UG=Hs.194766 /LL=23544 /DEF=Homo sapiens mRNA for KIAA0927 protein, partial cds. /PROD=KIAA0927 protein" 233.95 205.97 -1.14 -0.94 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
4 211894_x_at seizure related 6 homolog (mouse)-like /// seizure related 6 homolog (mouse)-like AB04173623544SEZ6L KIAA0927 "gb:AB041736.1 /DEF=Homo sapiens mRNA for SEZ6L, complete cds. /FEA=CDS /GEN=SEZ6L /PROD=SEZ6L /DB_XREF=gi:13603397 /FL=gb:AB041736.1" 582.53 521.56 -1.12 -1.01 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction

Sample Description:
Primary culture of human pancreatic islet was treated with cAMP agonist forskolin (FSK) and compared with control untreated samples. RNA was extracted using the Qiagen RNeasy kit. Two control and two forskolin treated samples were analyzed.

Microarray Analysis:
Total RNA samples were labeled and hybridized by standard protocol to Affymetrix GeneChip Human Genome U133A 2.0 Array. Array data was analyzed using the dChip software with PM-MM models.

Guidelines for Choosing camp Induced Genes in this Data Set:
The fold change (FC) value is positive for increased expression and negative for decrease expression. There is also a lower bound of fold change (LFC), which is a conservative estimation of the fold change with 90% confidence. For this data set, if a gene was induced by FSK with LFC>=1.3, we consider it as a good camp induced gene and therefore a potential CREB target.