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No probe set Gene Name Accession LocusLink Symbol Alias Symbols Description CTRL FSK (FSK vs CTRL) FC (FSK vs CTRL) LFC Note Link
1 220999_s_at cytoplasmic FMR1 interacting protein 2 /// cytoplasmic FMR1 interacting protein 2 NM_03077826999CYFIP2 PIR121;PRO1331 "gb:NM_030778.1 /DEF=Homo sapiens hypothetical protein PRO1331 (PRO1331), mRNA. /FEA=mRNA /GEN=PRO1331 /PROD=hypothetical protein PRO1331 /DB_XREF=gi:13562115 /FL=gb:NM_030778.1" 143.22 125.17 -1.14 -0.94 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
2 215785_s_at cytoplasmic FMR1 interacting protein 2 AL16199926999CYFIP2 PIR121;PRO1331 Consensus includes gb:AL161999.1 /DEF=Homo sapiens mRNA; cDNA DKFZp761H087 (from clone DKFZp761H087); partial cds. /FEA=mRNA /GEN=DKFZp761H087 /PROD=hypothetical protein /DB_XREF=gi:7328000 /UG=Hs.258503 p53 inducible protein 402.74 347.14 -1.16 -1.04 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction

Sample Description:
Primary culture of human pancreatic islet was treated with cAMP agonist forskolin (FSK) and compared with control untreated samples. RNA was extracted using the Qiagen RNeasy kit. Two control and two forskolin treated samples were analyzed.

Microarray Analysis:
Total RNA samples were labeled and hybridized by standard protocol to Affymetrix GeneChip Human Genome U133A 2.0 Array. Array data was analyzed using the dChip software with PM-MM models.

Guidelines for Choosing camp Induced Genes in this Data Set:
The fold change (FC) value is positive for increased expression and negative for decrease expression. There is also a lower bound of fold change (LFC), which is a conservative estimation of the fold change with 90% confidence. For this data set, if a gene was induced by FSK with LFC>=1.3, we consider it as a good camp induced gene and therefore a potential CREB target.