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No probe set Gene Name Accession LocusLink Symbol Alias Symbols Description CTRL FSK (FSK vs CTRL) FC (FSK vs CTRL) LFC Note Link
1 90610_at leucine-rich repeats and calponin homology (CH) domain containing 4 AI6548574034LRRN4 LRN;LRRN1 "Cluster Incl. AI654857:wb65b10.x1 Homo sapiens cDNA, 3 end /clone=IMAGE-2310523 /clone_end=3' /gb=AI654857 /gi=4738836 /ug=Hs.160115 /len=621" 977.82 1021.61 1.04 0.92 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
2 204692_at leucine-rich repeats and calponin homology (CH) domain containing 4 NM_0023194034LRRN4 LRN;LRRN1 "gb:NM_002319.1 /DEF=Homo sapiens leucine-rich neuronal protein (LRN), mRNA. /FEA=mRNA /GEN=LRN /PROD=leucine-rich neuronal protein /DB_XREF=gi:4505012 /UG=Hs.125742 leucine-rich neuronal protein /FL=gb:NM_002319.1" 238.78 247.54 1.04 0.84 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
3 222017_x_at leucine-rich repeats and calponin homology (CH) domain containing 4 AI6600754034LRRN4 LRN;LRRN1 Consensus includes gb:AI660075 /FEA=EST /DB_XREF=gi:4763645 /DB_XREF=est:we56c08.x1 /CLONE=IMAGE:2345102 /UG=Hs.125742 leucine-rich neuronal protein 115.9 119.64 1.03 0.29 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
4 37796_at leucine-rich repeats and calponin homology (CH) domain containing 4 AF0533564034LRRN4 LRN;LRRN1 " Cluster Incl. AF053356:Homo sapiens chromosome 7q22 sequence /cds=(0,2498) /gb=AF053356 /gi=3135305 /ug=Hs.125742 /len=2836 " 380.68 370.15 -1.03 -0.83 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
5 221956_at leucine-rich repeats and calponin homology (CH) domain containing 4 AI6318814034LRRN4 LRN;LRRN1 Consensus includes gb:AI631881 /FEA=EST /DB_XREF=gi:4683211 /DB_XREF=est:wa37c06.x1 /CLONE=IMAGE:2300266 /UG=Hs.125742 leucine-rich neuronal protein 283.82 248.49 -1.14 -0.84 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction

Sample Description:
Primary culture of human pancreatic islet was treated with cAMP agonist forskolin (FSK) and compared with control untreated samples. RNA was extracted using the Qiagen RNeasy kit. Two control and two forskolin treated samples were analyzed.

Microarray Analysis:
Total RNA samples were labeled and hybridized by standard protocol to Affymetrix GeneChip Human Genome U133A 2.0 Array. Array data was analyzed using the dChip software with PM-MM models.

Guidelines for Choosing camp Induced Genes in this Data Set:
The fold change (FC) value is positive for increased expression and negative for decrease expression. There is also a lower bound of fold change (LFC), which is a conservative estimation of the fold change with 90% confidence. For this data set, if a gene was induced by FSK with LFC>=1.3, we consider it as a good camp induced gene and therefore a potential CREB target.