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No probe set Gene Name Accession LocusLink Symbol Alias Symbols Description CTRL FSK (FSK vs CTRL) FC (FSK vs CTRL) LFC Note Link
1 211591_s_at "phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)" L209655141PDE4A DPDE2 "gb:L20965.1 /DEF=Human phosphodiesterase mRNA, complete cds. /FEA=mRNA /PROD=phosphodiesterase /DB_XREF=gi:347119 /UG=Hs.89901 phosphodiesterase 4A, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E2) /FL=gb:L20965.1 gb:U18087.1 gb:M37744.1" 126.63 128.85 1.02 0.84 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
2 211901_s_at "phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)" AF0737455141PDE4A DPDE2 "gb:AF073745.2 /DEF=Homo sapiens cyclic AMP-specific phosphodiesterase HSPDE4A10 (PDE4A) mRNA, complete cds. /FEA=CDS /GEN=PDE4A /PROD=cyclic AMP-specific phosphodiesterase HSPDE4A10 /DB_XREF=gi:12057220 /UG=Hs.89901 phosphodiesterase 4A, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E2) /FL=gb:AF073745.2" 121.39 126.91 1.05 0.81 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
3 204735_at "phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)" NM_0062025141PDE4A DPDE2 "gb:NM_006202.1 /DEF=Homo sapiens phosphodiesterase 4A, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E2) (PDE4A), mRNA. /FEA=mRNA /GEN=PDE4A /PROD=phosphodiesterase 4A, cAMP-specific (dunce(Drosophila)-homolog phosphodiesterase E2) /DB_XREF=gi:5453861 /UG=Hs.89901 phosphodiesterase 4A, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E2) /FL=gb:U97584.1 gb:U68532.1 gb:NM_006202.1" 224.87 206.09 -1.09 -0.91 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction

Sample Description:
Primary culture of human pancreatic islet was treated with cAMP agonist forskolin (FSK) and compared with control untreated samples. RNA was extracted using the Qiagen RNeasy kit. Two control and two forskolin treated samples were analyzed.

Microarray Analysis:
Total RNA samples were labeled and hybridized by standard protocol to Affymetrix GeneChip Human Genome U133A 2.0 Array. Array data was analyzed using the dChip software with PM-MM models.

Guidelines for Choosing camp Induced Genes in this Data Set:
The fold change (FC) value is positive for increased expression and negative for decrease expression. There is also a lower bound of fold change (LFC), which is a conservative estimation of the fold change with 90% confidence. For this data set, if a gene was induced by FSK with LFC>=1.3, we consider it as a good camp induced gene and therefore a potential CREB target.