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No probe set Gene Name Accession LocusLink Symbol Alias Symbols Description CTRL FSK (FSK vs CTRL) FC (FSK vs CTRL) LFC Note Link
1 209698_at chromosome 6 open reading frame 18 AF21649354535C6orf18 HCR "gb:AF216493.1 /DB_XREF=gi:8272481 /GEN=HCR /FEA=FLmRNA /CNT=65 /TID=Hs.110746.0 /TIER=FL+Stack /STK=20 /UG=Hs.110746 /LL=54535 /DEF=Homo sapiens a-helical protein (HCR) mRNA, complete cds. /PROD=a-helical protein /FL=gb:AB029331.1 gb:AF216493.1 gb:NM_019052.1" 751.52 816.63 1.09 0.9 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
2 37424_at chromosome 6 open reading frame 18 AB02934354535C6orf18 HCR " Cluster Incl. AB029343:Homo sapiens HCR (a-helix coiled-coil rod homologue) gene, complete cds /cds=(22,2292) /gb=AB029343 /gi=5360900 /ug=Hs.110746 /len=2445 " 161.1 184.82 1.15 0.77 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
3 42361_g_at chromosome 6 open reading frame 18 AI58898654535C6orf18 HCR "Cluster Incl. AI588986:tk15g03.x1 Homo sapiens cDNA, 3 end /clone=IMAGE-2151124 /clone_end=3' /gb=AI588986 /gi=4598034 /ug=Hs.236209 /len=499" 83.92 71.81 -1.17 -0.98 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
4 37425_g_at chromosome 6 open reading frame 18 AB02934354535C6orf18 HCR " Cluster Incl. AB029343:Homo sapiens HCR (a-helix coiled-coil rod homologue) gene, complete cds /cds=(22,2292) /gb=AB029343 /gi=5360900 /ug=Hs.110746 /len=2445 " 766.14 650.72 -1.18 -1.12 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction

Sample Description:
Primary culture of human pancreatic islet was treated with cAMP agonist forskolin (FSK) and compared with control untreated samples. RNA was extracted using the Qiagen RNeasy kit. Two control and two forskolin treated samples were analyzed.

Microarray Analysis:
Total RNA samples were labeled and hybridized by standard protocol to Affymetrix GeneChip Human Genome U133A 2.0 Array. Array data was analyzed using the dChip software with PM-MM models.

Guidelines for Choosing camp Induced Genes in this Data Set:
The fold change (FC) value is positive for increased expression and negative for decrease expression. There is also a lower bound of fold change (LFC), which is a conservative estimation of the fold change with 90% confidence. For this data set, if a gene was induced by FSK with LFC>=1.3, we consider it as a good camp induced gene and therefore a potential CREB target.