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No probe set Gene Name Accession LocusLink Symbol Alias Symbols Description CTRL FSK (FSK vs CTRL) FC (FSK vs CTRL) LFC Note Link
1 220248_x_at NSFL1 (p97) cofactor (p47) NM_01883955968NSFL1C MGC3347;dJ776F14.1;p47 "gb:NM_018839.1 /DEF=Homo sapiens p47 protein (LOC55968), mRNA. /FEA=mRNA /GEN=LOC55968 /PROD=p47 protein /DB_XREF=gi:10047113 /UG=Hs.284261 p47 protein /FL=gb:NM_018839.1 gb:AF112211.1" 513.53 531.48 1.03 0.95 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
2 217831_s_at NSFL1 (p97) cofactor (p47) NM_01614355968NSFL1C MGC3347;dJ776F14.1;p47 "gb:NM_016143.1 /DEF=Homo sapiens p47 (LOC51674), mRNA. /FEA=mRNA /GEN=LOC51674 /PROD=p47 /DB_XREF=gi:7706394 /UG=Hs.12865 p47 /FL=gb:BC002801.1 gb:AF078856.1 gb:NM_016143.1" 415.13 428.51 1.03 0.89 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
3 217830_s_at NSFL1 (p97) cofactor (p47) NM_01614355968NSFL1C MGC3347;dJ776F14.1;p47 "Consensus includes gb:AL109658 /DEF=Human DNA sequence from clone RP4-776F14 on chromosome 20p12.2-13. Contains the 5 end of the FKBP1A gene for FK506-binding protein 1A (12kD), the gene for P47 protein, part of a novel member of the PTPNS (protein tyrosine phosphatase, non-recepto... /FEA=mRNA /DB_XREF=gi:7161806 /UG=Hs.12865 p47 /FL=gb:BC002801.1 gb:AF078856.1 gb:NM_016143.1" 233.55 208.64 -1.12 -0.95 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction

Sample Description:
Primary culture of human pancreatic islet was treated with cAMP agonist forskolin (FSK) and compared with control untreated samples. RNA was extracted using the Qiagen RNeasy kit. Two control and two forskolin treated samples were analyzed.

Microarray Analysis:
Total RNA samples were labeled and hybridized by standard protocol to Affymetrix GeneChip Human Genome U133A 2.0 Array. Array data was analyzed using the dChip software with PM-MM models.

Guidelines for Choosing camp Induced Genes in this Data Set:
The fold change (FC) value is positive for increased expression and negative for decrease expression. There is also a lower bound of fold change (LFC), which is a conservative estimation of the fold change with 90% confidence. For this data set, if a gene was induced by FSK with LFC>=1.3, we consider it as a good camp induced gene and therefore a potential CREB target.