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No probe set Gene Name Accession LocusLink Symbol Alias Symbols Description CTRL FSK (FSK vs CTRL) FC (FSK vs CTRL) LFC Note Link
1 211917_s_at prolactin receptor /// prolactin receptor AF3499395618PRLR  "gb:AF349939.1 /DEF=Homo sapiens prolactin receptor isoform delta S1 precursor, mRNA, complete cds. /FEA=CDS /PROD=prolactin receptor isoform delta S1 precursor /DB_XREF=gi:13605397 /FL=gb:AF349939.1" 103.39 114.94 1.11 0.94 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
2 210476_s_at prolactin receptor AF1663295618PRLR  "gb:AF166329.1 /DB_XREF=gi:5734139 /FEA=FLmRNA /CNT=11 /TID=Hs.1906.1 /TIER=FL /STK=0 /UG=Hs.1906 /LL=5618 /UG_GENE=PRLR /DEF=Homo sapiens intermediate prolactin receptor isoform mRNA, complete cds. /PROD=intermediate prolactin receptor isoform /FL=gb:AF166329.1" 159.43 162.94 1.02 0.83 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
3 216638_s_at prolactin receptor S785055618PRLR  "Consensus includes gb:S78505.1 /DEF=Homo sapiens prolactin receptor mRNA, partial cds. /FEA=mRNA /PROD=prolactin receptor /DB_XREF=gi:999114 /UG=Hs.1906 prolactin receptor" 144.43 131.63 -1.1 -0.72 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
4 206346_at prolactin receptor NM_0009495618PRLR  "gb:NM_000949.1 /DEF=Homo sapiens prolactin receptor (PRLR), mRNA. /FEA=mRNA /GEN=PRLR /PROD=prolactin receptor /DB_XREF=gi:4506106 /UG=Hs.1906 prolactin receptor /FL=gb:M31661.1 gb:NM_000949.1" 68.87 44.37 -1.55 -1.13 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction

Sample Description:
Primary culture of human pancreatic islet was treated with cAMP agonist forskolin (FSK) and compared with control untreated samples. RNA was extracted using the Qiagen RNeasy kit. Two control and two forskolin treated samples were analyzed.

Microarray Analysis:
Total RNA samples were labeled and hybridized by standard protocol to Affymetrix GeneChip Human Genome U133A 2.0 Array. Array data was analyzed using the dChip software with PM-MM models.

Guidelines for Choosing camp Induced Genes in this Data Set:
The fold change (FC) value is positive for increased expression and negative for decrease expression. There is also a lower bound of fold change (LFC), which is a conservative estimation of the fold change with 90% confidence. For this data set, if a gene was induced by FSK with LFC>=1.3, we consider it as a good camp induced gene and therefore a potential CREB target.