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No probe set Gene Name Accession LocusLink Symbol Alias Symbols Description CTRL FSK (FSK vs CTRL) FC (FSK vs CTRL) LFC Note Link
1 65591_at WD repeat endosomal protein N6468157599KIAA1449 P80 "Cluster Incl. N64681:yz87g05.s1 Homo sapiens cDNA, 3 end /clone=IMAGE-290072 /clone_end=3' /gb=N64681 /gi=1212510 /ug=Hs.239120 /len=606" 810.55 814.24 1 0.96 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
2 221735_at WD repeat endosomal protein H0434257599KIAA1449 P80 Consensus includes gb:H04342 /FEA=EST /DB_XREF=gi:867275 /DB_XREF=est:yj10g11.s1 /CLONE=IMAGE:148388 /UG=Hs.109778 KIAA1449 protein 266.84 277.79 1.04 0.91 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
3 222157_s_at WD repeat endosomal protein AB04088257599KIAA1449 P80 "Consensus includes gb:AB040882.1 /DEF=Homo sapiens mRNA for KIAA1449 protein, partial cds. /FEA=mRNA /GEN=KIAA1449 /PROD=KIAA1449 protein /DB_XREF=gi:7959156 /UG=Hs.109778 KIAA1449 protein" 275.58 268.92 -1.02 -0.94 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
4 56919_at WD repeat endosomal protein AI80662857599KIAA1449 P80 "Cluster Incl. AI806628:wf14g08.x1 Homo sapiens cDNA, 3 end /clone=IMAGE-2350622 /clone_end=3' /gb=AI806628 /gi=5393194 /ug=Hs.109778 /len=557" 357.93 345.12 -1.04 -0.94 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction

Sample Description:
Primary culture of human pancreatic islet was treated with cAMP agonist forskolin (FSK) and compared with control untreated samples. RNA was extracted using the Qiagen RNeasy kit. Two control and two forskolin treated samples were analyzed.

Microarray Analysis:
Total RNA samples were labeled and hybridized by standard protocol to Affymetrix GeneChip Human Genome U133A 2.0 Array. Array data was analyzed using the dChip software with PM-MM models.

Guidelines for Choosing camp Induced Genes in this Data Set:
The fold change (FC) value is positive for increased expression and negative for decrease expression. There is also a lower bound of fold change (LFC), which is a conservative estimation of the fold change with 90% confidence. For this data set, if a gene was induced by FSK with LFC>=1.3, we consider it as a good camp induced gene and therefore a potential CREB target.