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No probe set Gene Name Accession LocusLink Symbol Alias Symbols Description CTRL FSK (FSK vs CTRL) FC (FSK vs CTRL) LFC Note Link
1 215771_x_at "ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)" X157865979RET CDHF12;HSCR1;MEN2A;MEN2B;MTC1;PTC;RET51 "Consensus includes gb:X15786.1 /DEF=Human ret-II gene. /FEA=mRNA /GEN=retII /DB_XREF=gi:36008 /UG=Hs.241572 golgi autoantigen, golgin subfamily a, 5" 163.4 189.21 1.16 0.94 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
2 205879_x_at "ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)" BC0042575979RET CDHF12;HSCR1;MEN2A;MEN2B;MTC1;PTC;RET51 "gb:BC004257.1 /DEF=Homo sapiens, ret proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung disease), clone MGC:10752, mRNA, complete cds. /FEA=mRNA /PROD=ret proto-oncogene (multiple endocrine neoplasiaMEN2A, MEN2B and medullary thyroid carcinoma 1,Hirschsprung disease) /DB_XREF=gi:13279040 /UG=Hs.287270 ret proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung disease) /FL=gb:NM_020630.1 gb:BC004257.1" 130.85 111.73 -1.17 -0.61 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
3 211421_s_at "ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)" M312135979RET CDHF12;HSCR1;MEN2A;MEN2B;MTC1;PTC;RET51 "gb:M31213.1 /DB_XREF=gi:190699 /FEA=FLmRNA /CNT=1 /TID=Hs.287270.5 /TIER=FL /STK=0 /UG=Hs.287270 /LL=5979 /UG_GENE=RET /UG_TITLE=ret proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung disease) /DEF=Human papillary thyroid carcinoma-encoded protein mRNA, complete cds. /FL=gb:M31213.1" 54.4 45.53 -1.19 -0.86 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction

Sample Description:
Primary culture of human pancreatic islet was treated with cAMP agonist forskolin (FSK) and compared with control untreated samples. RNA was extracted using the Qiagen RNeasy kit. Two control and two forskolin treated samples were analyzed.

Microarray Analysis:
Total RNA samples were labeled and hybridized by standard protocol to Affymetrix GeneChip Human Genome U133A 2.0 Array. Array data was analyzed using the dChip software with PM-MM models.

Guidelines for Choosing camp Induced Genes in this Data Set:
The fold change (FC) value is positive for increased expression and negative for decrease expression. There is also a lower bound of fold change (LFC), which is a conservative estimation of the fold change with 90% confidence. For this data set, if a gene was induced by FSK with LFC>=1.3, we consider it as a good camp induced gene and therefore a potential CREB target.