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No probe set Gene Name Accession LocusLink Symbol Alias Symbols Description CTRL FSK (FSK vs CTRL) FC (FSK vs CTRL) LFC Note Link
1 203772_at "gb:U34877.1 /DB_XREF=gi:1143231 /FEA=FLmRNA /CNT=85 /TID=Hs.81029.0 /TIER=ConsEnd /STK=0 /UG=Hs.81029 /LL=644 /UG_GENE=BLVRA /DEF=Homo sapiens biliverdin-IX alpha reductase mRNA, complete cds. /PROD=biliverdin-IX alpha reductase /FL=gb:NM_000712.1 gb:U34877.1" U34877644BLVRA BLVR;BVRA "gb:U34877.1 /DB_XREF=gi:1143231 /FEA=FLmRNA /CNT=85 /TID=Hs.81029.0 /TIER=ConsEnd /STK=0 /UG=Hs.81029 /LL=644 /UG_GENE=BLVRA /DEF=Homo sapiens biliverdin-IX alpha reductase mRNA, complete cds. /PROD=biliverdin-IX alpha reductase /FL=gb:NM_000712.1 gb:U34877.1" 331.9 350.05 1.05 0.9 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
2 203771_s_at biliverdin reductase A AA740186644BLVRA BLVR;BVRA gb:AA740186 /DB_XREF=gi:2778778 /DB_XREF=ob26e06.s1 /CLONE=IMAGE:1324834 /FEA=FLmRNA /CNT=85 /TID=Hs.81029.0 /TIER=Stack /STK=12 /UG=Hs.81029 /LL=644 /UG_GENE=BLVRA /UG_TITLE=biliverdin reductase A /FL=gb:NM_000712.1 gb:U34877.1 295.9 286.28 -1.03 -0.91 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
3 211729_x_at biliverdin reductase A /// biliverdin reductase A BC005902644BLVRA BLVR;BVRA "gb:BC005902.1 /DB_XREF=gi:13543488 /FEA=FLmRNA /CNT=1 /TID=HsAffx.900751.522 /TIER=FL /STK=0 /DEF=Homo sapiens, Similar to biliverdin reductase A, clone MGC:14491, mRNA, complete cds. /PROD=Similar to biliverdin reductase A /FL=gb:BC005902.1" 933.56 820.67 -1.14 -1.02 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
4 203773_x_at biliverdin reductase A NM_000712644BLVRA BLVR;BVRA "gb:NM_000712.1 /DB_XREF=gi:4502416 /GEN=BLVRA /FEA=FLmRNA /CNT=85 /TID=Hs.81029.0 /TIER=FL+Stack /STK=20 /UG=Hs.81029 /LL=644 /DEF=Homo sapiens biliverdin reductase A (BLVRA), mRNA. /PROD=biliverdin reductase A /FL=gb:NM_000712.1 gb:U34877.1" 966.06 842.06 -1.15 -1.03 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction

Sample Description:
Primary culture of human pancreatic islet was treated with cAMP agonist forskolin (FSK) and compared with control untreated samples. RNA was extracted using the Qiagen RNeasy kit. Two control and two forskolin treated samples were analyzed.

Microarray Analysis:
Total RNA samples were labeled and hybridized by standard protocol to Affymetrix GeneChip Human Genome U133A 2.0 Array. Array data was analyzed using the dChip software with PM-MM models.

Guidelines for Choosing camp Induced Genes in this Data Set:
The fold change (FC) value is positive for increased expression and negative for decrease expression. There is also a lower bound of fold change (LFC), which is a conservative estimation of the fold change with 90% confidence. For this data set, if a gene was induced by FSK with LFC>=1.3, we consider it as a good camp induced gene and therefore a potential CREB target.