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No probe set Gene Name Accession LocusLink Symbol Alias Symbols Description CTRL FSK (FSK vs CTRL) FC (FSK vs CTRL) LFC Note Link
1 208078_s_at SNF1-like kinase /// SNF1-like kinase NM_0307516935TCF8 AREB6;BZP;NIL-2-A;NIL-2A;ZEB;ZEB1;ZFHEP;ZFHX1A "gb:NM_030751.1 /DEF=Homo sapiens transcription factor 8 (represses interleukin 2 expression) (TCF8), mRNA. /FEA=mRNA /GEN=TCF8 /PROD=transcription factor 8 (represses interleukin 2expression) /DB_XREF=gi:13540478 /FL=gb:NM_030751.1" 328.12 2411.99 7.35 5.31 "all, CREBtarget" HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
2 210875_s_at transcription factor 8 (represses interleukin 2 expression) U121706935TCF8 AREB6;BZP;NIL-2-A;NIL-2A;ZEB;ZEB1;ZFHEP;ZFHX1A "gb:U12170.1 /DEF=Human zinc finger homeodomain protein mRNA, complete cds. /FEA=mRNA /PROD=zinc finger homeodomain protein /DB_XREF=gi:529172 /UG=Hs.232068 transcription factor 8 (represses interleukin 2 expression) /FL=gb:U12170.1" 291.17 352.43 1.21 1.08 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
3 212764_at transcription factor 8 (represses interleukin 2 expression) AI3731666935TCF8 AREB6;BZP;NIL-2-A;NIL-2A;ZEB;ZEB1;ZFHEP;ZFHX1A Consensus includes gb:AI806174 /FEA=EST /DB_XREF=gi:5392740 /DB_XREF=est:wf06h03.x1 /CLONE=IMAGE:2349845 /UG=Hs.232068 transcription factor 8 (represses interleukin 2 expression) 447.29 453.75 1.01 0.94 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
4 212758_s_at transcription factor 8 (represses interleukin 2 expression) AI3731666935TCF8 AREB6;BZP;NIL-2-A;NIL-2A;ZEB;ZEB1;ZFHEP;ZFHX1A gb:AI373166 /DB_XREF=gi:4153032 /DB_XREF=qz13b01.x1 /CLONE=IMAGE:2021353 /FEA=mRNA /CNT=125 /TID=Hs.232068.2 /TIER=Stack /STK=20 /UG=Hs.232068 /LL=6935 /UG_GENE=TCF8 /UG_TITLE=transcription factor 8 (represses interleukin 2 expression) 221.11 228.25 1.03 0.92 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction

Sample Description:
Primary culture of human pancreatic islet was treated with cAMP agonist forskolin (FSK) and compared with control untreated samples. RNA was extracted using the Qiagen RNeasy kit. Two control and two forskolin treated samples were analyzed.

Microarray Analysis:
Total RNA samples were labeled and hybridized by standard protocol to Affymetrix GeneChip Human Genome U133A 2.0 Array. Array data was analyzed using the dChip software with PM-MM models.

Guidelines for Choosing camp Induced Genes in this Data Set:
The fold change (FC) value is positive for increased expression and negative for decrease expression. There is also a lower bound of fold change (LFC), which is a conservative estimation of the fold change with 90% confidence. For this data set, if a gene was induced by FSK with LFC>=1.3, we consider it as a good camp induced gene and therefore a potential CREB target.