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No probe set Gene Name Accession LocusLink Symbol Alias Symbols Description CTRL FSK (FSK vs CTRL) FC (FSK vs CTRL) LFC Note Link
1 214864_s_at glyoxylate reductase/hydroxypyruvate reductase AK0243869380GRHPR GLXR "gb:AK024386.1 /DB_XREF=gi:10436760 /FEA=mRNA /CNT=11 /TID=Hs.155742.2 /TIER=ConsEnd /STK=0 /UG=Hs.155742 /LL=9380 /UG_GENE=GRHPR /UG_TITLE=glyoxylate reductasehydroxypyruvate reductase /DEF=Homo sapiens cDNA FLJ14324 fis, clone PLACE4000100, highly similar to Homo sapiens hydroxypyruvate reductase (GRHPR) gene." 599.43 651.36 1.09 0.99 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
2 216308_x_at glyoxylate reductase/hydroxypyruvate reductase AK0267529380GRHPR GLXR "Consensus includes gb:AK026752.1 /DEF=Homo sapiens cDNA: FLJ23099 fis, clone LNG07460, highly similar to AF113251 Homo sapiens putative 2-hydroxyacid dehydrogenase mRNA. /FEA=mRNA /DB_XREF=gi:10439675 /UG=Hs.155742 glyoxylate reductasehydroxypyruvate reductase" 798.12 820.68 1.03 0.96 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction
3 201347_x_at glyoxylate reductase/hydroxypyruvate reductase NM_0122039380GRHPR GLXR "gb:NM_012203.1 /DEF=Homo sapiens glyoxylate reductasehydroxypyruvate reductase (GRHPR), mRNA. /FEA=mRNA /GEN=GRHPR /PROD=glyoxylate reductasehydroxypyruvate reductase /DB_XREF=gi:6912395 /UG=Hs.155742 glyoxylate reductasehydroxypyruvate reductase /FL=gb:AF113215.1 gb:BC000605.1 gb:BC003131.1 gb:AF146018.1 gb:AF113251.1 gb:AF134895.1 gb:NM_012203.1" 807.71 819.77 1.01 0.91 "all, " HEK293T_Expression Human_ChIP_chip Human_CRE_prediction

Sample Description:
Primary culture of human pancreatic islet was treated with cAMP agonist forskolin (FSK) and compared with control untreated samples. RNA was extracted using the Qiagen RNeasy kit. Two control and two forskolin treated samples were analyzed.

Microarray Analysis:
Total RNA samples were labeled and hybridized by standard protocol to Affymetrix GeneChip Human Genome U133A 2.0 Array. Array data was analyzed using the dChip software with PM-MM models.

Guidelines for Choosing camp Induced Genes in this Data Set:
The fold change (FC) value is positive for increased expression and negative for decrease expression. There is also a lower bound of fold change (LFC), which is a conservative estimation of the fold change with 90% confidence. For this data set, if a gene was induced by FSK with LFC>=1.3, we consider it as a good camp induced gene and therefore a potential CREB target.